John H Zhang Selected Research

Brain Edema (Cerebral Edema)

1/2022	Met-RANTES preserves the blood-brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice.
9/2021	Activation of Frizzled-7 attenuates blood-brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice.
3/2021	Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice.
1/2021	INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.
1/2021	TREM (Triggering Receptor Expressed on Myeloid Cells)-1 Inhibition Attenuates Neuroinflammation via PKC (Protein Kinase C) δ/CARD9 (Caspase Recruitment Domain Family Member 9) Signaling Pathway After Intracerebral Hemorrhage in Mice.
1/2021	SPARC Aggravates Blood-Brain Barrier Disruption via Integrin αVβ3/MAPKs/MMP-9 Signaling Pathway after Subarachnoid Hemorrhage.
10/2020	Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage.
10/2020	Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice.
10/2020	Pituitary Adenylate Cyclase-Activating Polypeptide Attenuates Brain Edema by Protecting Blood-Brain Barrier and Glymphatic System After Subarachnoid Hemorrhage in Rats.
5/2020	TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice.

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John H Zhang Research Topics

Disease

182	Brain Injuries (Brain Injury) 08/2022 - 09/2002
123	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 12/2021 - 02/2002
114	Brain Edema (Cerebral Edema) 01/2022 - 08/2004
71	Hypoxia (Hypoxemia) 01/2022 - 09/2002
64	Ischemia 01/2021 - 02/2002
60	Cerebral Hemorrhage 11/2022 - 05/2004
60	Inflammation (Inflammations) 01/2022 - 07/2005
59	Hemorrhage 05/2020 - 02/2002
57	Stroke (Strokes) 10/2021 - 05/2004
50	Infarction (Infarctions) 01/2022 - 02/2002
46	Neuroinflammatory Diseases 02/2022 - 04/2010
44	Brain Ischemia (Cerebral Ischemia) 05/2020 - 02/2002
43	Ischemic Stroke 02/2021 - 09/2003
31	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 02/2021 - 07/2006
23	Wounds and Injuries (Trauma) 01/2020 - 07/2005
22	Intracranial Vasospasm 01/2019 - 02/2002
21	Hematoma 01/2022 - 05/2004
17	Brain Infarction 01/2022 - 07/2003
17	Edema (Dropsy) 12/2020 - 04/2005
13	Hydrocephalus (Hydrocephaly) 02/2022 - 01/2011
13	Atrophy 01/2021 - 11/2009
11	Hyperglycemia 10/2021 - 03/2007
11	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2020 - 06/2011
11	Body Weight (Weight, Body) 10/2016 - 03/2007
10	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 05/2020 - 02/2010
9	Neurologic Manifestations (Neurological Manifestations) 10/2020 - 07/2003
9	Reperfusion Injury 02/2019 - 05/2004
8	Hemorrhagic Stroke 01/2018 - 03/2010
6	Neoplasms (Cancer) 08/2019 - 01/2005
5	Alzheimer Disease (Alzheimer's Disease) 01/2019 - 04/2010
5	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2017 - 05/2008
4	Seizures (Absence Seizure) 10/2020 - 03/2008
4	Asphyxia (Suffocation) 10/2020 - 07/2018

Drug/Important Bio-Agent (IBA)

63	Oxygen (Dioxygen)IBA 01/2018 - 02/2002
48	Proteins (Proteins, Gene)FDA Link 08/2022 - 02/2002
38	salicylhydroxamic acid (SHAM)IBA 01/2019 - 09/2003
37	Neuroprotective AgentsIBA 12/2020 - 07/2006
30	Small Interfering RNA (siRNA)IBA 01/2021 - 03/2009
26	Caspase 3 (Caspase-3)IBA 01/2021 - 07/2003
22	HydrogenIBA 01/2021 - 08/2008
18	CytokinesIBA 02/2021 - 11/2003
18	OsteopontinIBA 01/2020 - 02/2010
16	Collagenases (Collagenase)FDA Link 01/2018 - 10/2004
14	Hemoglobins (Hemoglobin)IBA 09/2021 - 02/2011
13	Matrix Metalloproteinases (MMPs)IBA 01/2021 - 07/2006
13	Evans Blue (Blue, Evans)FDA Link 07/2017 - 07/2006
12	fluoro-jade CIBA 01/2022 - 03/2016
12	Isoflurane FDA LinkGeneric 10/2020 - 07/2010
12	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 03/2007
12	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2016 - 08/2004
12	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 10/2015 - 01/2007
11	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2021 - 10/2004
11	Therapeutic UsesIBA 01/2019 - 03/2002
10	AntioxidantsIBA 01/2022 - 01/2008
10	Phosphotransferases (Kinase)IBA 01/2019 - 02/2011
9	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021 - 05/2004
9	Pharmaceutical PreparationsIBA 11/2020 - 12/2009
9	Anesthetics (Anesthetic Agents)IBA 10/2020 - 03/2009
9	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2016 - 02/2002
9	Messenger RNA (mRNA)IBA 01/2012 - 02/2002
8	Sirtuin 1IBA 10/2021 - 02/2015
8	CateninsIBA 09/2021 - 04/2012
8	Peroxidase (Myeloperoxidase)IBA 01/2018 - 06/2008
7	Tight Junction ProteinsIBA 01/2022 - 11/2009
7	IntegrinsIBA 01/2021 - 11/2010
7	Thrombin FDA Link 01/2021 - 04/2009
7	Protein Kinases (Protein Kinase)IBA 01/2021 - 08/2004
7	Erythropoietin FDA Link 01/2015 - 02/2004
7	hydrogen rich salineIBA 04/2011 - 04/2009
6	Adenosine Triphosphate (ATP)IBA 12/2021 - 07/2002
6	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 03/2021 - 07/2003
6	InflammasomesIBA 01/2021 - 10/2013
6	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2017 - 02/2002
6	Mitogen-Activated Protein KinasesIBA 01/2016 - 03/2002
6	Free RadicalsIBA 01/2016 - 04/2005
6	MelatoninIBA 01/2011 - 01/2008
6	NADPH Oxidases (NAD(P)H oxidase)IBA 08/2007 - 02/2004
5	Immunoglobulin G (IgG)IBA 01/2021 - 04/2008
5	Interleukin-6 (Interleukin 6)IBA 01/2021 - 11/2003
5	Adenosine Monophosphate (AMP)IBA 10/2020 - 04/2017
5	Malondialdehyde (Propanedial)IBA 01/2020 - 03/2009
5	Glycoproteins (Glycoprotein)IBA 01/2018 - 02/2010
5	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2018 - 01/2011
5	Fingolimod Hydrochloride (FTY720)FDA Link 01/2017 - 02/2010
5	Coloring Agents (Dyes)IBA 01/2016 - 02/2011
5	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA 06/2015 - 09/2009
4	LigandsIBA 01/2022 - 10/2020
4	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 10/2021 - 10/2019
4	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2021 - 01/2018
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2018
4	NF-kappa B (NF-kB)IBA 01/2021 - 02/2010
4	Peptides (Polypeptides)IBA 12/2020 - 01/2011
4	Circular RNAIBA 11/2020 - 01/2018

Therapy/Procedure

66	Therapeutics 01/2021 - 03/2002
41	Ligation 01/2022 - 09/2002
19	Hyperbaric Oxygenation 01/2018 - 09/2002
13	Neurosurgical Procedures 01/2020 - 03/2007
11	Intranasal Administration 01/2021 - 11/2013
9	Electrocoagulation (Electrocautery) 01/2019 - 01/2007
5	Sutures (Suture) 01/2016 - 07/2006